Climate change is a severe threat to humankind. To keep global warming limited to 1.5C, it must reach net-zero emission by 2050. It is ambitious and challenging for Laos to achieve the target. The main objective of this paper is to identify the challenges and solutions to the decarbonization pathway in Laos. The net-zero emission by 2025 goal is too ambitious for Laos and the LDC countries, and there are several challenges, including human resources, funding, and technologies. Achieving the target requires extensive funding, human resources, and technologies. Therefore, the roles of developed countries and international donors are crucial.