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Book cover for Model Systems in Biology: History, Philosophy, and Practical Concerns

Model Systems in Biology: History, Philosophy, and Practical Concerns

By
Georg Striedter
Georg Striedter

Georg Striedter is Professor in the Department of Neurobiology and Behavior at the University of California, Irvine. He is the author of two books on nervous system evolution, as well as an introductory college-level textbook, Neurobiology: A Functional Approach.

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The MIT Press
DOI:
https://doi.org/10.7551/mitpress/14366.001.0001
ISBN electronic:
9780262370028
Publication date:
2022

Contents

  1. Title Page
  2. Copyright Page
  3. Table of Contents
  4. Preface
  5. 1. Crises in Biomedical Research
    1. 1.1. The Translatability Crisis
    2. 1.2. The Replicability Crisis
    3. 1.3. Reckoning with Biological Variation
    4. 1.4. Which Model Is “Best”?
    5. 1.5. This Book’s Approach and Organization
  6. 2. Philosophy of Models in Biology
    1. 2.1. Abstract Models
    2. 2.2. Material Models
    3. 2.3. Assumptions about Model Fidelity
    4. 2.4. Dealing with Biological Complexity
    5. 2.5. Animal Welfare and Cognitive Dissonance
    6. 2.6. Comparative Biology and August Krogh Revisited
  7. 3. A History of Animal Models
    1. 3.1. Eclectic Beginnings of Biology
    2. 3.2. Early Experimental Medicine: Research on Pet Species
    3. 3.3. Fruit Flies: The First Supermodel
    4. 3.4. Laboratory Rats: The First Standardized Mammals
    5. 3.5. Laboratory Mice: From Cancer Fighter to Model Organism
    6. 3.6. Nonhuman Primates
    7. 3.7. The Rest of the Menagerie
    8. 3.8. Model System Ecology
  8. 4. A History of in Vitro Models
    1. 4.1. Microbial Models
    2. 4.2. Cell and Tissue Culture Models
    3. 4.3. Alternative Models in Toxicology
    4. 4.4. Model Ecology Revisited
  9. 5. Models and Therapies: Infectious Diseases, Cardiovascular Disease, and Cancer
    1. 5.1. Infectious Diseases
    2. 5.2. Cardiovascular Diseases
    3. 5.3. Cancers
    4. 5.4. Patterns of Model Use
  10. 6. Neurological Disorders: Trials and Tribulations
    1. 6.1. Brain and Spinal Cord Injuries
    2. 6.2. Neurodegenerative Disorders
    3. 6.3. Neuropsychiatric Disorders
    4. 6.4. Successes, Failures, Hopes
  11. 7. Diagnosis and Recommendations
    1. 7.1. Four Perspectives on Models in Biology
    2. 7.2. Recommendations
    3. 7.3. Conclusion
  12. Appendix
  13. References
  14. Index
html-cover-page title_page copyright contents preface chapter_1 chapter_2 chapter_3 chapter_4 chapter_5 chapter_6 chapter_7 appendix references index