Abstract
Fundamental physics began the twentieth century with the twin revolutions of relativity and quantum mechanics, and much of the second half of the century was devoted to the construction of a theoretical structure unifying these radical ideas. But this foundation has also led us to a number of paradoxes in our understanding of nature. Attempts to make sense of quantum mechanics and gravity at the smallest distance scales lead inexorably to the conclusion that space-time is an approximate notion that must emerge from more primitive building blocks. Furthermore, violent short-distance quantum fluctuations in the vacuum seem to make the existence of a macroscopic world wildly implausible, and yet we live comfortably in a huge universe. What, if anything, tames these fluctuations? Why is there a macroscopic universe? These are two of the central theoretical challenges of fundamental physics in the twenty-first century. In this essay, I describe the circle of ideas surrounding these questions, as well as some of the theoretical and experimental fronts on which they are being attacked.