The twenty-first century is witnessing rapid and deep change in the global economy. These changes require innovation-driven solutions and motivated, skilled workforces. The talents of every person will be required to support performance in every domain, and deliberate actions must be taken to address impediments to full engagement. Even with clear government policy and significant investments in encouraging representation and inclusion of diversity of race, sexual orientation, gender identity, and ability, progress continues to lag. This essay captures promising practices and recommendations for structural or systemic change punctuated with stories of leadership driven by the belief that implementing strategies to disrupt the effects of implicit bias are important to develop diverse, fully engaged populations.