ABSTRACT The Covid-19 pandemic is affecting health, social, mental, and economic well-being worldwide, and taking precautions and co-operation is crucial at the individual level. Using data from various sources, this study examines cross-country differences in anxiety levels and behavioral responses to the Covid-19 pandemic. Specifically, I investigate how economic preferences and development at the country-level are associated with anxiety and behavioral response and whether these factors explain contextual differences. Results show that anxiety was less common among more patient and developed societies. Yet, altruistic societies suffered more from anxiety. Higher levels of positive reciprocity and trust were also associated with stronger health-protective behavioral responses. These findings are important in eliciting the consequences of the Covid-19 pandemic for different societies during the ongoing pandemic.