The superficial white matter, the layer of white matter immediately deep to the cortical grey matter, is a highly complex, heterogeneous tissue region comprising dense meshes of neural fibres, a robust population of interstitial neurons, and ongoing glial activity and myelination. It originates from the histologically distinct, developmentally vital subplate in the fetal brain, maintains thalamo-cortical connections throughout adult life, and is a necessary passage for all axons passing between the grey and white matter. Despite these features, the superficial white matter is among the most poorly understood regions of the brain, in part due to its complex makeup and the resulting difficulty of its study. In this review, we review our current knowledge of SWM anatomy, development, and response to disease. We discuss the unique challenges encountered in the neuroimaging of this region, including the lack of standard definition and the nonspecificity of neuroimaging markers amplified by the complexity of the tissue. We discuss recent innovations and offer potential pathways forward.

This content is only available as a PDF.

Author notes

These authors contributed equally.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. For a full description of the license, please visit https://creativecommons.org/licenses/by/4.0/legalcode.

Article PDF first page preview

Article PDF first page preview