Reaction-Diffusion (RD) systems provide a computational framework that governs many pattern formation processes in nature. Current RD system design practices boil down to trial-and-error parameter search. We propose a differentiable optimization method for learning the RD system parameters to perform example-based texture synthesis on a 2D plane. We do this by representing the RD system as a variant of Neural Cellular Automata and using task-specific differentiable loss functions. RD systems generated by our method exhibit robust, non-trivial “life-like” behavior.