Language production requires that semantic representations are mapped to lexical representations on the basis of the ongoing context to select the appropriate words. This mapping is thought to generate two opposing phenomena, “semantic priming,” where multiple word candidates are activated, and “interference,” where these word activities are differentiated to make a goal-relevant selection. In previous neuroimaging and neurophysiological research, priming and interference have been associated to activity in regions of a left frontotemporal network. Most of such studies relied on recordings that either have high temporal or high spatial resolution, but not both. Here, we employed intracerebral EEG techniques to explore with both high resolutions, the neural activity associated with these phenomena. The data came from nine epileptic patients who were stereotactically implanted for presurgical diagnostics. They performed a cyclic picture-naming task contrasting semantically homogeneous and heterogeneous contexts. Of the 84 brain regions sampled, 39 showed task-evoked activity that was significant and consistent across two patients or more. In nine of these regions, activity was significantly modulated by the semantic manipulation. It was reduced for semantically homogeneous contexts (i.e., priming) in eight of these regions, located in the temporal ventral pathway as well as frontal areas. Conversely, it was increased only in the pre-SMA, notably at an early poststimulus temporal window (200–300 msec) and a preresponse temporal window (700–800 msec). These temporal effects respectively suggest the pre-SMA's role in initial conflict detection (e.g., increased response caution) and in preresponse control. Such roles of the pre-SMA are traditional from a history of neural evidence in simple perceptual tasks, yet are also consistent with recent cognitive lexicosemantic theories that highlight top–down processes in language production. Finally, although no significant semantic modulation was found in the ACC, future intracerebral EEG work should continue to inspect ACC with the pre-SMA.

Through study of clinical cases with brain lesions as well as neuroimaging studies of cognitive processing of words and pictures, it has been established that material-specific hemispheric specialization exists. It remains however unclear whether such specialization holds true for all processes involved in complex tasks, such as recognition memory. To investigate neural signatures of transition from perception to recognition, according to type of material (words or abstract pictures), high-resolution scalp ERPs were recorded in adult humans engaged either in categorization or in memory recognition tasks within the same experimental setup. Several steps in the process from perception to recognition were identified. Source localization showed that the early stage of perception processing (N170) takes place in the fusiform gyrus and is lateralized according to the nature of stimuli (left side for words and right side for pictures). Late stages of processing (N400/P600) corresponding to recognition are material independent and involve anterior medial-temporal and ventral prefrontal structures bilaterally. A crucial transitional process between perception (N170) and recognition (N400/P600) is reflected by the N270, an often overlooked component, which occurs in anterior rhinal cortices and shows material-specific hemispheric lateralization.