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Ima Trempler
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Journal Articles
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2022) 34 (7): 1287–1305.
Published: 02 June 2022
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Episodic memories are not static but can change on the basis of new experiences, potentially allowing us to make valid predictions in the face of an ever-changing environment. Recent research has identified prediction errors during memory retrieval as a possible trigger for such changes. In this study, we used modified episodic cues to investigate whether different types of mnemonic prediction errors modulate brain activity and subsequent memory performance. Participants encoded episodes that consisted of short toy stories. During a subsequent fMRI session, participants were presented videos showing the original episodes, or slightly modified versions thereof. In modified videos, either the order of two subsequent action steps was changed or an object was exchanged for another. Content modifications recruited parietal, temporo-occipital, and parahippocampal areas reflecting the processing of the new object information. In contrast, structure modifications elicited activation in right dorsal premotor, posterior temporal, and parietal areas, reflecting the processing of new sequence information. In a post-fMRI memory test, the participants' tendency to accept modified episodes as originally encoded increased significantly when they had been presented modified versions already during the fMRI session. After experiencing modifications, especially those of the episodes' structure, the recognition of originally encoded episodes was impaired as well. Our study sheds light onto the neural processing of different types of episodic prediction errors and their influence on subsequent memory recall.
Journal Articles
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2020) 32 (2): 326–337.
Published: 01 February 2020
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The processing of congruent stimuli, such as an object or action in its typical location, is usually associated with reduced neural activity, probably due to facilitated recognition. However, in some situations, congruency increases neural activity—for example, when objects next to observed actions are likely versus unlikely to be involved in forthcoming action steps. Here, we investigated using fMRI whether the processing of contextual cues during action perception is driven by their (in)congruency and, thus, informative value to make sense of an observed scene. Specifically, we tested whether both highly congruent contextual objects (COs), which strongly indicate a future action step, and highly incongruent COs, which require updating predictions about possible forthcoming action steps, provide more anticipatory information about the action course than moderately congruent COs. In line with our hypothesis that especially the inferior frontal gyrus (IFG) subserves the integration of the additional information into the predictive model of the action, we found highly congruent and incongruent COs to increase bilateral activity in action observation nodes, that is, the IFG, the occipitotemporal cortex, and the intraparietal sulcus. Intriguingly, BA 47 was significantly stronger engaged for incongruent COs reflecting the updating of prediction in response to conflicting information. Our findings imply that the IFG reflects the informative impact of COs on observed actions by using contextual information to supply and update the currently operating predictive model. In the case of an incongruent CO, this model has to be reconsidered and extended toward a new overarching action goal.
Journal Articles
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2017) 29 (2): 298–309.
Published: 01 February 2017
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Surprising events may be relevant or irrelevant for behavior, requiring either flexible adjustment or stabilization of our model of the world and according response strategies. Cognitive flexibility and stability in response to environmental demands have been described as separable cognitive states, associated with activity of striatal and lateral prefrontal regions, respectively. It so far remains unclear, however, whether these two states act in an antagonistic fashion and which neural mechanisms mediate the selection of respective responses, on the one hand, and a transition between these states, on the other. In this study, we tested whether the functional dichotomy between striatal and prefrontal activity applies for the separate functions of updating (in response to changes in the environment, i.e., switches) and shielding (in response to chance occurrences of events violating expectations, i.e., drifts) of current predictions. We measured brain activity using fMRI while 20 healthy participants performed a task that required to serially predict upcoming items. Switches between predictable sequences had to be indicated via button press while sequence omissions (drifts) had to be ignored. We further varied the probability of switches and drifts to assess the neural network supporting the transition between flexible and stable cognitive states as a function of recent performance history in response to environmental demands. Flexible switching between models was associated with activation in medial pFC (BA 9 and BA 10), whereas stable maintenance of the internal model corresponded to activation in the lateral pFC (BA 6 and inferior frontal gyrus). Our findings extend previous studies on the interplay of flexibility and stability, suggesting that different prefrontal regions are activated by different types of prediction errors, dependent on their behavioral requirements. Furthermore, we found that striatal activation in response to switches and drifts was modulated by participants' successful behavior toward these events, suggesting the striatum to be responsible for response selections following unpredicted stimuli. Finally, we observed that the dopaminergic midbrain modulates the transition between different cognitive states, thresholded by participants' individual performance history in response to temporal environmental demands.