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Joey W. Trampush
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Journal Articles
A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology
UnavailablePublisher: Journals Gateway
Journal of Cognitive Neuroscience (2015) 27 (9): 1766–1774.
Published: 01 September 2015
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View articletitled, A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology
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for article titled, A Common Polymorphism in SCN2A Predicts General Cognitive Ability through Effects on PFC Physiology
Here we provide novel convergent evidence across three independent cohorts of healthy adults ( n = 531), demonstrating that a common polymorphism in the gene encoding the α2 subunit of neuronal voltage-gated type II sodium channels ( SCN2A ) predicts human general cognitive ability or “ g .” Using meta-analysis, we demonstrate that the minor T allele of a common polymorphism (rs10174400) in SCN2A is associated with significantly higher “ g ” independent of gender and age. We further demonstrate using resting-state fMRI data from our discovery cohort ( n = 236) that this genetic advantage may be mediated by increased capacity for information processing between the dorsolateral PFC and dorsal ACC, which support higher cognitive functions. Collectively, these findings fill a gap in our understanding of the genetics of general cognitive ability and highlight a specific neural mechanism through which a common polymorphism shapes interindividual variation in “ g. ”