Skip Nav Destination
Close Modal
Update search
NARROW
Format
Journal
Date
Availability
1-3 of 3
Sricharana Rajagopal
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Journal Articles
Gabriela Vélez Largo, Abdelhalim Elshiekh, Sricharana Rajagopal, Stamatoula Pasvanis, M. Natasha Rajah
Publisher: Journals Gateway
Journal of Cognitive Neuroscience 1–20.
Published: 23 February 2025
Abstract
View articletitled, Slower Postencoding Stimulus Reaction Time Predicts Poorer Subsequent Source Memory and Increased Midline Cortical Activity
View
PDF
for article titled, Slower Postencoding Stimulus Reaction Time Predicts Poorer Subsequent Source Memory and Increased Midline Cortical Activity
Individuals vary widely in their ability to encode and retrieve past personal experiences in rich contextual detail (episodic memory). However, it remains unclear how within-subject variations in attention, measured on a trial-by-trial basis at encoding, and between-subject variation in attention and executive function abilities affect encoding-related brain activity and subsequent episodic retrieval. In the present study, 38 healthy young adults (mean age = 26.5 ± 4.4, 21 females) completed a task fMRI study in which they were instructed to encode colored photographs of everyday objects and their left/right spatial location. In addition, participants were asked to respond as quickly as possible to a central fixation cross that expanded in size at a variable duration after each encoding trial. RTs to the fixation cross preceding and following the object were hypothesized to reflect attentional variations pre- and postencoding stimulus, respectively. A mixed-effects logistic regression was performed to predict source memory success from pre- and poststimulus RT. Slower poststimulus RT, but not prestimulus RT, predicted poorer subsequent source memory within-subject. In addition, between-subject variation in task-switching ability, self-reported cognitive failures, and self-reported attentional abilities affected the association between poststimulus RT and subsequent memory. In addition, trial-by-trial task fMRI analysis indicated that increased encoding activity within default mode network regions was associated with slower poststimulus RT and with subsequent source retrieval failures. These results shed light onto the cognitive and neural factors that contribute to within-subject and between-subject variations in source memory ability.
Journal Articles
Sivaniya Subramaniapillai, Sricharana Rajagopal, Elizabeth Ankudowich, Stamatoula Pasvanis, Bratislav Misic ...
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2022) 34 (8): 1500–1520.
Published: 01 July 2022
FIGURES
| View All (6)
Abstract
View articletitled, Age- and Episodic Memory-related Differences in Task-based Functional Connectivity in Women and Men
View
PDF
for article titled, Age- and Episodic Memory-related Differences in Task-based Functional Connectivity in Women and Men
Aging is associated with episodic memory decline and changes in functional brain connectivity. Understanding whether and how biological sex influences age- and memory performance-related functional connectivity has important theoretical implications for the cognitive neuroscience of memory and aging. Here, we scanned 161 healthy adults between 19 and 76 years of age in an event-related fMRI study of face–location spatial context memory. Adults were scanned while performing easy and difficult versions of the task at both encoding and retrieval. We used multivariate whole-brain partial least squares connectivity to test the hypothesis that there are sex differences in age- and episodic memory performance-related functional connectivity. We examined how individual differences in age and retrieval accuracy correlated with task-related connectivity. We then repeated this analysis after disaggregating the data by self-reported sex. We found that increased encoding and retrieval-related connectivity within the dorsal attention network (DAN), and between DAN and frontoparietal network and visual networks, were positively correlated to retrieval accuracy and negatively correlated with age in both sexes. We also observed sex differences in age- and performance-related functional connectivity: (a) Greater between-networks integration was apparent at both levels of task difficulty in women only, and (b) increased DAN–default mode network connectivity with age was observed in men and was correlated with poorer memory performance. Therefore, the neural correlates of age-related episodic memory decline differ in women and men and have important theoretical and clinical implications for the cognitive neuroscience of memory, aging, and dementia prevention.
Journal Articles
Sivaniya Subramaniapillai, Sricharana Rajagopal, Abdelhalim Elshiekh, Stamatoula Pasvanis, Elizabeth Ankudowich ...
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2019) 31 (12): 1895–1916.
Published: 01 December 2019
FIGURES
| View All (7)
Abstract
View articletitled, Sex Differences in the Neural Correlates of Spatial Context Memory Decline in Healthy Aging
View
PDF
for article titled, Sex Differences in the Neural Correlates of Spatial Context Memory Decline in Healthy Aging
Aging is associated with episodic memory decline and alterations in memory-related brain function. However, it remains unclear if age-related memory decline is associated with similar patterns of brain aging in women and men. In the current task fMRI study, we tested the hypothesis that there are sex differences in the effect of age and memory performance on brain activity during episodic encoding and retrieval of face–location associations (spatial context memory). Forty-one women and 41 men between the ages of 21 and 76 years participated in this study. Between-group multivariate partial least squares analysis of the fMRI data was conducted to directly test for sex differences and similarities in age-related and performance-related patterns of brain activity. Our behavioral analysis indicated no significant sex differences in retrieval accuracy on the fMRI tasks. In relation to performance effects, we observed similarities and differences in how retrieval accuracy related to brain activity in women and men. Both sexes activated dorsal and lateral PFC, inferior parietal cortex, and left parahippocampal gyrus at encoding, and this supported subsequent memory performance. However, there were sex differences in retrieval activity in these same regions and in lateral occipital-temporal and ventrolateral PFC. In relation to age effects, we observed sex differences in the effect of age on memory-related activity within PFC, inferior parietal cortex, parahippocampal gyrus, and lateral occipital-temporal cortices. Overall, our findings suggest that the neural correlates of age-related spatial context memory decline differ in women compared with men.