Skip Nav Destination
Close Modal
Update search
NARROW
Format
Journal
TocHeadingTitle
Date
Availability
1-2 of 2
Susan Y. Bookheimer
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Sort by
Journal Articles
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2015) 27 (6): 1194–1206.
Published: 01 June 2015
FIGURES
| View All (11)
Abstract
View article
PDF
Examining the function of individual human hippocampal subfields remains challenging because of their small sizes and convoluted structures. Previous human fMRI studies at 3 T have successfully detected differences in activation between hippocampal cornu ammonis (CA) field CA1, combined CA2, CA3, and dentate gyrus (DG) region (CA23DG), and the subiculum during associative memory tasks. In this study, we investigated hippocampal subfield activity in healthy participants using an associative memory paradigm during high-resolution fMRI scanning at 7 T. We were able to localize fMRI activity to anterior CA2 and CA3 during learning and to the posterior CA2 field, the CA1, and the posterior subiculum during retrieval of novel associations. These results provide insight into more specific human hippocampal subfield functions underlying learning and memory and a unique opportunity for future investigations of hippocampal subfield function in healthy individuals as well as those suffering from neurodegenerative diseases.
Journal Articles
Publisher: Journals Gateway
Journal of Cognitive Neuroscience (2004) 16 (3): 427–438.
Published: 01 April 2004
Abstract
View article
PDF
Artificial grammar learning (Reber, 1967) is a form of implicit learning in which cognitive, rather than motor, implicit learning has been found. After viewing a series of letter strings formed according to a finite state rule system, people are able to classify new letter strings as to whether or not they are formed according to these grammatical rules despite little conscious insight into the rule structure. Previous research has shown that these classification judgments are based on knowledge of abstract rules as well as superficial similarity (“chunk strength”) to training strings. Here we used event-related fMRI to identify neural regions involved in using both sources of information as test stimuli were designed to unconfound chunk strength from rule use. Using functional connectivity analyses, the extent to which the sources of information are complementary or competitive was also assessed. Activation in the right caudate was associated with rule adherence, whereas medial temporal lobe activations were associated with chunk strength. Additionally, functional connectivity analyses revealed caudate and medial temporal lobe activations to be strongly negatively correlated (r = −88) with one another during the performance of this task.