To overcome unhealthy behaviors, one must be able to make better choices. Changing food preferences is an important strategy in addressing the obesity epidemic and its accompanying public health risks. However, little is known about how food preferences can be effectively affected and what neural systems support such changes. In this study, we investigated a novel extensive training paradigm where participants chose from specific pairs of palatable junk food items and were rewarded for choosing the items with lower subjective value over higher value ones. In a later probe phase, when choices were made for real consumption, participants chose the lower-valued item more often in the trained pairs compared with untrained pairs. We replicated the behavioral results in an independent sample of participants while they were scanned with fMRI. We found that, as training progressed, there was decreased recruitment of regions that have been previously associated with cognitive control, specifically the left dorsolateral pFC and bilateral parietal cortices. Furthermore, we found that connectivity of the left dorsolateral pFC was greater with primary motor regions by the end of training for choices of lower-valued items that required exertion of self-control, suggesting a formation of a stronger stimulus–response association. These findings demonstrate that it is possible to influence food choices through training and that this training is associated with a decreasing need for top–down frontoparietal control. The results suggest that training paradigms may be promising as the basis for interventions to influence real-world food preferences.

Hemispheric lateralization of emotional processing has long been suggested, but its underlying neural mechanisms have not yet been defined. In this functional magnetic resonance imaging study, facial expressions were presented to 10 right-handed healthy adult females in an event-related visual half-field presentation paradigm. Differential activations to fearful versus neutral faces were observed in the amygdala, pulvinar, and superior colliculus only for faces presented in the left hemifield. Interestingly, the left hemifield advantage for fear processing was observed in both hemispheres. These results suggest a leftward bias in subcortical fear processing, consistent with the well-documented leftward bias of danger-associated behaviors in animals. The current finding highlights the importance of hemifield advantage in emotional lateralization, which might reflect the combination of hemispheric dominance and asymmetric interhemispheric information transfer.