Artists and psychologists have been experimenting with synesthesia for centuries. The author provides a historical review to show that artists and psychologists have always had great difficulty manipulating and controlling the phenomenon of synesthesia. Within these limits, artistic experiments with color organs, musical paintings and visual music have primarily uncovered perceptual and emotional aspects of synesthesia. Psychological experiments have produced a variety of methodologies to aid the study of synesthesia. Currently, psychologists approach synesthesia foremost as a neurological phenomenon, while artists generally explore digital devices to simulate synesthesia.