The author works with microorganisms that produce colored natural pigments to create biopaintings that result from the manipulation of organisms and their specific interactions. The author's biopaintings were obtained by controlling the growth of yeast cells on paper, ensuring the stability of the final results. These biopaintings resulted from the artist's observation and experimentation with evolving patterns of yeast biofilms. The often-unexpected results are part of the creative process and suggest new artistic methodologies to be explored. An overview of the aesthetic manipulation of microorganisms by other artists is briefly presented.