The marriage of art and science often requires the sharing of unique characteristics. Skeletal muscle cells have provided a format in which the biology mimics the interaction of the artist and scientist within a common framework. This interaction, like the complex mechanism of fused muscle cells themselves, reveals and reminds those in both disciplines of the remarkable dynamic of movement between the two fields. This movement stimulates and rewards the artist and the scientist alike. For a scientist who works closely with artists, it is important to re-visit the fundamental concepts that drive the curiosity and stimulate the passion.