Recent investigational studies have indicated that fronto-orbital, temporal and parietal lobes have a decisive role in artistic creation and personal identification of “beauty” in painting. Moreover, visual artistic work and preferences could be modified by central nervous system diseases or external stimuli such as transcranial magnetic stimulation. Both creation and preferences would depend on prior art education and sociocultural norms. However, the superior activity of the brain remains of paramount importance in production and evaluation of paintings regardless of the style, representational or abstract. Therefore, redefinition of art by neuroaesthetic principles will create a better communication between the public and the artists.