What aspects of the human condition must art address? One way or another, all creatives engage in truth wrestling, struggling to reveal or redress essential elements of who and where we are in the world. How might a garden demonstrate cancer as part of life? How do we (re)consider art and neurotechnology, even (or perhaps especially) as human perception increasingly integrates technology, both externally and internally? How might a decentralized view of crypto art, including artists, collectors, gallerists, art historians and data scientists, indicate broader implications of block chain for society? The creative practices and scholarship featured in this issue of Leonardo, and across our organization and community, help identify current and emerging patterns in the human condition, anticipate related consequences and forecast scenarios that guide insight and action today. Leonardo wrestles with the truth of who we are in the world, and who might we yet become.

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