The phenomena of the universe form a common focus for the interrelationship between art that has space as its central concern and the astronomical sciences, as both disciplines strive to observe and express the mysteries of the cosmos. An unwavering mutual interest in space and mutual respect for each discipline form the nexus between the two. Some scientific projects have artist-in-residence programs that promote innovative art/science dialogues. Although most residencies are designed for the short term, one has certainly stood the test of time. The authors analyze one 15-year collaboration between visual artist Karel Nel and Caltech’s Cosmic Evolution Survey, COSMOS.