ABSTRACT This report on the first-ever Art-Science Interface session at the annual Kavli Frontiers of Science Symposium collects reflections from a number of the session’s invited participants as well as its organizers. What impact does the participation of artists have at an elite science research symposium? How does cross-disciplinary engagement of this kind both reflect on, and take part in, the larger conversation concerning art-science collaborations and the significance of their outcomes? These questions and others are briefly explored.