In this transcribed conversation, three artists from the U.K. research group The Cultural Negotiation of Science (CNoS) share the generational perspectives they bring to the contested field of arts-science research. Traversing territories between art-practice, physics, genetics and critical theory, their practice-based strategies actively destabilize the binary nature of cross-disciplinary dialogue in productive ways, allowing the spaces between artistic and scientific modes of inquiry to become sites of learning, both within and beyond academic institutions.