This article seeks to strengthen the epistemic case for sci-art by demonstrating how partnerships across paradigms can combine methodologies rooted in multiple knowledge traditions. Drawing on Robin Nelson’s multimodal conceptualization of artistic research and Bruno Latour’s model of science as a circulatory system of heterogeneous human and nonhuman phenomena, the author characterizes sci-art as a form of posthuman praxis, which opens new epistemic positions through transversal forms of inquiry, thereby revealing shared human/nonhuman cultures. Sci-art is thus proposed as a means of drawing together humans and nonhumans into more productive, empathic associations.