“La Durance, parcours et regards” is the title of an audiovisual experiment (2003–2004) carried out in association with the laboratory “Environment, genome, evolution” (EGEE/Aix Marseille Université). Conceived at first as a scientific documentary, the project advanced mixing different approaches, including biology, biodiversity, eco-paleontology, history, geography, sociology and arts. The support of new digital technologies appeared a better way than a linear documentary to reproduce a multidisciplinary conception and the complexity of the Durance River.