Outreach activities at the interface of science and art present a unique opportunity to connect and engage with “latently interested” publics who do not otherwise take part in science activities such as visiting science museums. In this article, the authors present “Guerilla Science” as one model that supports the hypothesis that well-designed science and art (STEAM) programming in informal settings can broaden participation in and facilitate engagement with STEM-related topics. The article describes a range of interactive events featuring scientists and artists and accompanying research into the impact of these events on a public audience.