This article is a brief review on the contemporary artistic epistemology and its use of the transdisciplinary practices as a form of developing artwork. The main objective is to analyze the artist’s interest and creativity on scientific issues and their peculiar view on new scientific and ecological paradigms to generate new knowledge, critical thinking, creative processes or new innovations. The author also explains his experience as researcher in the Institute of Microbiology at San Francisco University of Quito, Ecuador, where perhaps his presence could have been viewed as an “invasion” of the laboratory. For that reason, he uses the expression “intruder artist”—“the scientific spaces” foreign visitor who tries to understand technical considerations on processes and experiments, so they could produce inspiration on new “hybrid” artworks.