This paper proposes to teach students biology through dance. Knowledge of nucleotides, amino acids, and structures of DNA and protein is used to create dance music and choreography. The three nucleotides (A, T, G, or C) making up the amino acids of selected proteins are converted into a musical note. In accordance with DNA’s double helix structure and base-pairing, the authors designed a low-cost, in-house Dance Dance Revolution (DDR) machine to allow for a dual player dance mode that requires students to synchronize their choreography during gameplay.