ABSTRACT The authors explore protein sonification issues using Morse code theory. Short musical phrases based on protein amino acids are used to compose protein music. Rhythms and tunes familiar to teenagers are also investigated, with the aim of producing different genres of protein music. A special musical instrument, the Chinese guzheng , can be employed to play the protein music. Experiment is carried out with different proteins, including the HIV main protease. It is hoped that this study can help unveil the mysteries of nature and motivate students to learn biology.