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Eran Stark
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Journal Articles
Publisher: Journals Gateway
Neural Computation (2017) 29 (3): 783–803.
Published: 01 March 2017
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Jitter-type spike resampling methods are routinely applied in neurophysiology for detecting temporal structure in spike trains (point processes). Several variations have been proposed. The concern has been raised, based on numerical experiments involving Poisson spike processes, that such procedures can be conservative. We study the issue and find it can be resolved by reemphasizing the distinction between spike-centered (basic) jitter and interval jitter. Focusing on spiking processes with no temporal structure, interval jitter generates an exact hypothesis test, guaranteeing valid conclusions. In contrast, such a guarantee is not available for spike-centered jitter. We construct explicit examples in which spike-centered jitter hallucinates temporal structure, in the sense of exaggerated false-positive rates. Finally, we illustrate numerically that Poisson approximations to jitter computations, while computationally efficient, can also result in inaccurate hypothesis tests. We highlight the value of classical statistical frameworks for guiding the design and interpretation of spike resampling methods.
Journal Articles
Publisher: Journals Gateway
Neural Computation (2008) 20 (9): 2133–2184.
Published: 01 September 2008
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Correlated neural activity has been observed at various signal levels (e.g., spike count, membrane potential, local field potential, EEG, fMRI BOLD). Most of these signals can be considered as superpositions of spike trains filtered by components of the neural system (synapses, membranes) and the measurement process. It is largely unknown how the spike train correlation structure is altered by this filtering and what the consequences for the dynamics of the system and for the interpretation of measured correlations are. In this study, we focus on linearly filtered spike trains and particularly consider correlations caused by overlapping presynaptic neuron populations. We demonstrate that correlation functions and statistical second-order measures like the variance, the covariance, and the correlation coefficient generally exhibit a complex dependence on the filter properties and the statistics of the presynaptic spike trains. We point out that both contributions can play a significant role in modulating the interaction strength between neurons or neuron populations. In many applications, the coherence allows a filter-independent quantification of correlated activity. In different network models, we discuss the estimation of network connectivity from the high-frequency coherence of simultaneous intracellular recordings of pairs of neurons.