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Journal Articles
Publisher: Journals Gateway
Neural Computation (2004) 16 (12): 2507–2532.
Published: 01 December 2004
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The basic requirement for direction selectivity is a nonlinear interaction between two different inputs in space-time. In some models, the interaction is hypothesized to occur between excitation and inhibition of the shunting type in the neuron's dendritic tree. How can the required spatial specificity be acquired in an unsupervised manner? We here propose an activity-based, local learning model that can account for direction selectivity in visual cortex based on such a local veto operation and that depends on synaptically induced changes in intracellular calcium concentration. Our biophysical simulations suggest that a model cell with our learning algorithm can develop direction selectivity organically after unsupervised training. The learning rule is also applicable to a neuron with multiple-direction-selective subunits and to a pair of cells with opposite-direction selectivities and is stable under different starting conditions, delays, and velocities.
Journal Articles
Publisher: Journals Gateway
Neural Computation (2004) 16 (11): 2221–2243.
Published: 01 November 2004
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Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia. We show that relatively simple mechanisms are sufficient to generate realistic trajectories for both the short-term response of axons to steep gradients and the long-term response of axons to shallow gradients. The model makes testable predictions for axonal response to attractive and repulsive gradients of different concentrations and steepness, the size of the intracellular amplification of the gradient signal, and the differences in intracellular signaling required for repulsive versus attractive turning.