Author Summary In a previous study implementing the Ising model on a 2D lattice, we showed that the joint synergistic information shared by two variables on a target one peaks before the transition to an ordered state (critical point). Here we implemented the same model on individual structural connectomes, to answer these questions: - Does the synergy still peak before the critical point in a nonuniform network? - Are the hubs of structural connectivity also hubs of synergy? - Is there association with age? We found that synergy still peaks before the critical temperature and that hubs of structural connectivity are not among the nodes towards which synergy is highest. Furthermore, using robust measures of association we found both positive and negative associations of synergy with age, in localized clusters. In some regions this association is continuous with age; in others it is limited to around the first 30 years of age. Abstract We implement the dynamical Ising model on the large-scale architecture of white matter connections of healthy subjects in the age range 4–85 years, and analyze the dynamics in terms of the synergy, a quantity measuring the extent to which the joint state of pairs of variables is projected onto the dynamics of a target one. We find that the amount of synergy in explaining the dynamics of the hubs of the structural connectivity (in terms of degree strength) peaks before the critical temperature, and can thus be considered as a precursor of a critical transition. Conversely, the greatest amount of synergy goes into explaining the dynamics of more central nodes. We also find that the aging of structural connectivity is associated with significant changes in the simulated dynamics: There are brain regions whose synergy decreases with age, in particular the frontal pole, the subcallosal area, and the supplementary motor area; these areas could then be more likely to show a decline in terms of the capability to perform higher order computation (if structural connectivity was the sole variable). On the other hand, several regions in the temporal cortex show a positive correlation with age in the first 30 years of life, that is, during brain maturation.

A fundamental challenge in preprocessing pipelines for neuroimaging datasets is to increase the signal-to-noise ratio for subsequent analyses. In the same line, we suggest here that the application of the consensus clustering approach to brain connectivity matrices can be a valid additional step for connectome processing to find subgroups of subjects with reduced intragroup variability and therefore increasing the separability of the distinct subgroups when connectomes are used as a biomarker. Moreover, by partitioning the data with consensus clustering before any group comparison (for instance, between a healthy population vs. a pathological one), we demonstrate that unique regions within each cluster arise and bring new information that could be relevant from a clinical point of view.

Visibility algorithms are a family of methods that map time series into graphs, such that the tools of graph theory and network science can be used for the characterization of time series. This approach has proved a convenient tool, and visibility graphs have found applications across several disciplines. Recently, an approach has been proposed to extend this framework to multivariate time series, allowing a novel way to describe collective dynamics. Here we test their application to fMRI time series, following two main motivations, namely that (a) this approach allows vs to simultaneously capture and process relevant aspects of both local and global dynamics in an easy and intuitive way, and (b) this provides a suggestive bridge between time series and network theory that nicely fits the consolidating field of network neuroscience. Our application to a large open dataset reveals differences in the similarities of temporal networks (and thus in correlated dynamics) across resting-state networks, and gives indications that some differences in brain activity connected to psychiatric disorders could be picked up by this approach. Author Summary Here we present the first application of multivariate visibility graphs to fMRI data. Visibility graphs are a way to represent a time series as a temporal network, evidencing specific aspects of its dynamics, such as extreme events. Multivariate time series, as those encountered in neuroscience, and in fMRI in particular, can be seen as a multiplex network, in which each layer represents a time series (a region of interest in the brain in our case). Here we report the method, we describe some relevant aspects of its application to BOLD time series, and we discuss the analogies and differences with existing methods. Finally, we present an application to a high-quality, publicly available dataset, containing healthy subjects and psychotic patients, and we discuss our findings. All the code to reproduce the analyses and the figures is publicly available.

A novel approach rooted on the notion of consensus clustering, a strategy developed for community detection in complex networks, is proposed to cope with the heterogeneity that characterizes connectivity matrices in health and disease. The method can be summarized as follows: (a) define, for each node, a distance matrix for the set of subjects by comparing the connectivity pattern of that node in all pairs of subjects; (b) cluster the distance matrix for each node; (c) build the consensus network from the corresponding partitions; and (d) extract groups of subjects by finding the communities of the consensus network thus obtained. Different from the previous implementations of consensus clustering, we thus propose to use the consensus strategy to combine the information arising from the connectivity patterns of each node. The proposed approach may be seen either as an exploratory technique or as an unsupervised pretraining step to help the subsequent construction of a supervised classifier. Applications on a toy model and two real datasets show the effectiveness of the proposed methodology, which represents heterogeneity of a set of subjects in terms of a weighted network, the consensus matrix.

Traumatic brain injury (TBI) affects structural connectivity, triggering the reorganization of structural–functional circuits in a manner that remains poorly understood. We focus here on brain network reorganization in relation to postural control deficits after TBI. We enrolled young participants who had suffered moderate to severe TBI, comparing them to young, typically developing control participants. TBI patients (but not controls) recruited prefrontal regions to interact with two separated networks: (1) a subcortical network, including parts of the motor network, basal ganglia, cerebellum, hippocampus, amygdala, posterior cingulate gyrus, and precuneus; and (2) a task-positive network, involving regions of the dorsal attention system, together with dorsolateral and ventrolateral prefrontal regions. We also found that the increased prefrontal connectivity in TBI patients was correlated with some postural control indices, such as the amount of body sway, whereby patients with worse balance increased their connectivity in frontal regions more strongly. The increased prefrontal connectivity found in TBI patients may provide the structural scaffolding for stronger cognitive control of certain behavioral functions, consistent with the observations that various motor tasks are performed less automatically following TBI and that more cognitive control is associated with such actions. Author Summary Using a new hierarchical atlas whose modules are relevant for both structure and function, we found increased structural and functional connectivity in prefrontal regions in TBI patients as compared to controls, in addition to a general pattern of overall decreased connectivity across the TBI brain. Although this increased prefrontal connectivity reflected interactions between brain areas when participants were at rest, the enhanced connectivity was found to be negatively correlated with active behavior such as postural control performance. Thus our findings, obtained when the brain was at rest, potentially reflect how TBI patients orchestrate task-related activations to support behavior in everyday life. In particular, our findings of enhanced connectivity in TBI might help these patients overcome deficits in cerebellar and subcortical connections, in addition to compensating for deficits when interacting with the task-positive network. Hence, it appears that greater cognitive control is exerted over certain actions in order to overcome deficits in their automatic processing.