When the “meme” was introduced in 1976, it was as a metaphor intended to illuminate an evolutionary argument. By the late-1980s, however, we see from its use in major US newspapers that this original meaning had become obscured. The meme became a virus of the mind. (In the UK, this occurred slightly later.) It is also now clear that this becoming involved complex sustained interactions between scholars, journalists, and the letter-writing public. We must therefore read the “meme” through lenses provided by its popularization. The results are in turn suggestive of the processes of meaning-construction in scholarly communication more generally.