This paper proposes a way to understand the meaning of reality (in science) on the basis of the concepts of persistence and resistance. It first supports the ontological view that reality consists of persistent potentialities, which resist being excluded from existence. A study of the cases of the Higgs boson and the hypothetical Ϝ-particle helps to illustrate how real entities persist and resist. The paper then suggests that, perceptually speaking, the results of ordinary perception or observational processes persistently appear under appropriate conditions, and they resist disappearance even when the appropriate conditions are not completely prepared. Finally, it argues that, epistemologically speaking, a truthful theory resists being falsified and persists across replicable observations and experiments.