Starting from the examination of a passage of the Dialogo sopra i massimi sistemi del mondo that has been largely ignored by the scholarship, in this paper I want to reveal the true nature of Galileo’s epistemology in terms of its epistemic ideal, that is that theory is capable of providing true and certain knowledge about natural phenomena coming from sensation. The investigation examines all the occurrences of the expression sensate esperienze in its singular and plural forms, both in the Latin and in the vernacular. The research proceeds diachronically through an analysis of Galileo’s writings taken in order to show the progressive development of his epistemology. The paper will demonstrate how in thinking about sensate experiences Galileo had in mind as epistemic paradigm that of the epistemology of anatomy.