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Table 2.

Coordinates of activated regions

Brain region(s)Extent (mm3)Max tMNI coordinatesp
xyz
Linguistic demand 
Left fusiform gyrus, inferior temporal gyrus, lingual gyrus, inferior and middle occipital lobe 33,432 13.61 −37 −71 −12 0.0017 
Left IFG pars opercularis and triangularis, inferior frontal sulcus, inferior frontal junction, precentral gyrus, anterior insula 30,224 7.20 −43 15 20 0.0028 
Right inferior occipital lobe 17,824 6.51 36 −78 −11 0.0085 
Bilateral thalamus, basal ganglia, midbrain 13,928 7.44 −3 −12 0.013 
Right IFG ascending ramus of the Sylvian fissure, inferior frontal junction, anterior insula 12,008 8.10 41 19 17 0.017 
Bilateral cerebellum 6,792 6.44 −71 −28 0.036 
Right pre-SMA/anterior-mid cingulate 5,680 6.20 24 38 0.046 
Negative linguistic demand 
Bilateral precuneus, posterior cingulate 37,016 9.86 −1 −53 29 0.0010 
Left angular gyrus 16,616 10.46 −45 −65 30 0.0091 
Right supramarginal gyrus, postcentral gyrus 15,408 5.21 48 −27 44 0.011 
Right angular gyrus 8,672 8.24 47 −66 31 0.027 
Bilateral ventromedial prefrontal cortex 7,280 5.64 49 −6 0.036 
Right posterior insula 5,712 5.84 41 −6 0.049 
Interaction of domain by difficulty 
Left IFG pars triangularis and orbitalis, superior temporal gyrus, STS, middle temporal gyrus, hippocampus 45,112 7.22 −47 −4 −9 0.0013 
Bilateral ventromedial prefrontal cortex, superior frontal gyrus 37,008 8.61 −1 50 18 0.0020 
Bilateral precuneus, posterior cingulate 26,840 7.70 −1 −51 28 0.0038 
Right superior temporal gyrus, STS, middle temporal gyrus 15,584 6.84 60 −14 −12 0.0099 
Negative interaction of domain by difficulty 
Much of the bilateral multiple demand network, cerebellum 232,624 10.66 −53 16 < 0.0001 
Left dorsal precentral gyrus and sulcus, superior frontal sulcus, pre-SMA, anterior-mid cingulate 14,776 7.47 −20 −1 54 0.012 
Left anterior insula, basal ganglia 7,672 6.84 −28 18 0.029 
Right thalamus 7,584 7.21 16 −15 11 0.029 
Brain region(s)Extent (mm3)Max tMNI coordinatesp
xyz
Linguistic demand 
Left fusiform gyrus, inferior temporal gyrus, lingual gyrus, inferior and middle occipital lobe 33,432 13.61 −37 −71 −12 0.0017 
Left IFG pars opercularis and triangularis, inferior frontal sulcus, inferior frontal junction, precentral gyrus, anterior insula 30,224 7.20 −43 15 20 0.0028 
Right inferior occipital lobe 17,824 6.51 36 −78 −11 0.0085 
Bilateral thalamus, basal ganglia, midbrain 13,928 7.44 −3 −12 0.013 
Right IFG ascending ramus of the Sylvian fissure, inferior frontal junction, anterior insula 12,008 8.10 41 19 17 0.017 
Bilateral cerebellum 6,792 6.44 −71 −28 0.036 
Right pre-SMA/anterior-mid cingulate 5,680 6.20 24 38 0.046 
Negative linguistic demand 
Bilateral precuneus, posterior cingulate 37,016 9.86 −1 −53 29 0.0010 
Left angular gyrus 16,616 10.46 −45 −65 30 0.0091 
Right supramarginal gyrus, postcentral gyrus 15,408 5.21 48 −27 44 0.011 
Right angular gyrus 8,672 8.24 47 −66 31 0.027 
Bilateral ventromedial prefrontal cortex 7,280 5.64 49 −6 0.036 
Right posterior insula 5,712 5.84 41 −6 0.049 
Interaction of domain by difficulty 
Left IFG pars triangularis and orbitalis, superior temporal gyrus, STS, middle temporal gyrus, hippocampus 45,112 7.22 −47 −4 −9 0.0013 
Bilateral ventromedial prefrontal cortex, superior frontal gyrus 37,008 8.61 −1 50 18 0.0020 
Bilateral precuneus, posterior cingulate 26,840 7.70 −1 −51 28 0.0038 
Right superior temporal gyrus, STS, middle temporal gyrus 15,584 6.84 60 −14 −12 0.0099 
Negative interaction of domain by difficulty 
Much of the bilateral multiple demand network, cerebellum 232,624 10.66 −53 16 < 0.0001 
Left dorsal precentral gyrus and sulcus, superior frontal sulcus, pre-SMA, anterior-mid cingulate 14,776 7.47 −20 −1 54 0.012 
Left anterior insula, basal ganglia 7,672 6.84 −28 18 0.029 
Right thalamus 7,584 7.21 16 −15 11 0.029 

Note. Coordinates are centers of mass.

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