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Table 2. 

Correlations (Fisher’s z-score) between global network indices and neuropsychological composites

Network indexControls (n = 40)
UPDRSWorking memProc speedMem comp
Node strength NA 0.225 0.021 0.230 
Clustering NA 0.079 0.149 0.195 
Path length NA 0.100 0.051 0.082 
Small-worldness NA −0.144 −0.076 −0.148 
Network indexPD-Well (n = 31)
UPDRSWorking memProc speedMem comp
Node strength 0.008 −0.574* 0.169 −0.179 
Clustering −0.287 0.018 0.251 0.076 
Path length 0.070 −0.594* 0.193 −0.229 
Small-worldness −0.172 0.115 0.230 −0.049 
Network indexPD-MI (n = 9)
UPDRSWorking memProc speedMem comp
Node strength 0.824# −0.314 −0.594# 0.116 
Clustering −0.071 −0.328 −0.685*# 0.356 
Path length 0.955# −0.826* −0.724*# 0.312 
Small-worldness −0.084 −0.109 −0.450 0.079 
Network indexControls (n = 40)
UPDRSWorking memProc speedMem comp
Node strength NA 0.225 0.021 0.230 
Clustering NA 0.079 0.149 0.195 
Path length NA 0.100 0.051 0.082 
Small-worldness NA −0.144 −0.076 −0.148 
Network indexPD-Well (n = 31)
UPDRSWorking memProc speedMem comp
Node strength 0.008 −0.574* 0.169 −0.179 
Clustering −0.287 0.018 0.251 0.076 
Path length 0.070 −0.594* 0.193 −0.229 
Small-worldness −0.172 0.115 0.230 −0.049 
Network indexPD-MI (n = 9)
UPDRSWorking memProc speedMem comp
Node strength 0.824# −0.314 −0.594# 0.116 
Clustering −0.071 −0.328 −0.685*# 0.356 
Path length 0.955# −0.826* −0.724*# 0.312 
Small-worldness −0.084 −0.109 −0.450 0.079 

UPDRS = Unified Parkinson’s Disease Rating Scale, Working mem = working-memory score, Proc speed = processing-speed composite score, Mem comp = memory composite score, and clustering = clustering coefficient score. Partial correlation controlled for age using Spearman’s method transformed to Fisher’s z-scores using the “psych” package in R. Black bins correspond to |z| > 0.55 and correlated results. * corresponds to statistically significant difference to controls; # corresponds to statistically significant difference to PD-Well, calculated from r values with http://vassarstats.net/rdiff.html.

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