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Table 2.

Research levels of the papers in the network models

A. Biological phenomenon Papers investigating CRISPR/Cas as bacterial immune systems; the interactions of their component in bacteria or archaea, and/or the molecular, ecological, or evolutionary interactions of these systems with the bacteriophage viruses. 
B. Developments or improvements of CRISPR/Cas technologies These papers report discoveries of alternative CRISPR/Cas genome editing systems that could be more efficient, more versatile, or easier to use; investigations aimed to overcome the technical difficulties to apply the technology in different organisms; or investigations reporting molecular mechanisms that can be used to modulate the activity of Cas enzymes. 
C. Other Papers in which CRISPR/Cas is not the central object of investigation but is an instrument to identify or analyze the role of specific genes in normal or pathological biological processes; papers reporting applications of CRISPR/Cas in biomedicine, food systems, environmental systems, or industrial biotechnology; or papers reporting the ethical or societal implications of CRISPR/Cas technologies. 
A. Biological phenomenon Papers investigating CRISPR/Cas as bacterial immune systems; the interactions of their component in bacteria or archaea, and/or the molecular, ecological, or evolutionary interactions of these systems with the bacteriophage viruses. 
B. Developments or improvements of CRISPR/Cas technologies These papers report discoveries of alternative CRISPR/Cas genome editing systems that could be more efficient, more versatile, or easier to use; investigations aimed to overcome the technical difficulties to apply the technology in different organisms; or investigations reporting molecular mechanisms that can be used to modulate the activity of Cas enzymes. 
C. Other Papers in which CRISPR/Cas is not the central object of investigation but is an instrument to identify or analyze the role of specific genes in normal or pathological biological processes; papers reporting applications of CRISPR/Cas in biomedicine, food systems, environmental systems, or industrial biotechnology; or papers reporting the ethical or societal implications of CRISPR/Cas technologies. 
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