Probability
. | Estimate
. | Interpretation
. | Evidence
. |
---|---|---|---|

P(T) | 0.24 | prior of T | posterior probability for W/C triple-helix |

P(∼T) | 0.76 | prior of ∼T | 1 − prior |

P(E1|T) | 0.7 | strongly consistent | B-form X-ray picture predicted by the Cochran-Crick-Vand theory |

P(E1|∼T) | 0.7 | strongly consistent | Triple helix also supported by the B-form X-ray |

P(E2|T) | 0.3 | strongly inconsistent | 34 Å crystallographic repeat for B-form not possible with like-with-like model |

P(E2|∼T) | 0.3 | strongly inconsistent | 34 Å crystallographic repeat for W/C triple helix not possible |

P(E3|T) | 0.3 | strongly inconsistent | Like-with-like bond lengths wrong |

P(E3|∼T) | 0.3 | strongly inconsistent | Triple-helix bond lengths wrong |

P(E4|T) | 0.3 | strongly inconsistent | Like-with-like C2 symmetry not present |

P(E4|∼T) | 0.3 | strongly inconsistent | Triple-helix C2 symmetry not present |

P(E5|T) | 0.3 | strongly inconsistent | Like-with-like Chargaff’s rules violated |

P(E5|∼T) | 0.3 | strongly inconsistent | Triple-helix Chargaff’s rules violated |

P(E6|T) | 0.3 | strongly inconsistent | Like-with-like hydrogen-bonding incorrect |

P(E6|∼T) | 0.3 | strongly inconsistent | Triple-helix hydrogen-bonds not possible |

P(E7|T) | 0.6 | weakly consistent | Like-with-like replication mechanism possible |

P(E7|∼T) | 0.4 | weakly inconsistent | Triple-helix had no replication mechanism |

P(T|E1–E7) | 0.32 | confirm | % change = +33.3, LR = 1.5 |

Probability
. | Estimate
. | Interpretation
. | Evidence
. |
---|---|---|---|

P(T) | 0.24 | prior of T | posterior probability for W/C triple-helix |

P(∼T) | 0.76 | prior of ∼T | 1 − prior |

P(E1|T) | 0.7 | strongly consistent | B-form X-ray picture predicted by the Cochran-Crick-Vand theory |

P(E1|∼T) | 0.7 | strongly consistent | Triple helix also supported by the B-form X-ray |

P(E2|T) | 0.3 | strongly inconsistent | 34 Å crystallographic repeat for B-form not possible with like-with-like model |

P(E2|∼T) | 0.3 | strongly inconsistent | 34 Å crystallographic repeat for W/C triple helix not possible |

P(E3|T) | 0.3 | strongly inconsistent | Like-with-like bond lengths wrong |

P(E3|∼T) | 0.3 | strongly inconsistent | Triple-helix bond lengths wrong |

P(E4|T) | 0.3 | strongly inconsistent | Like-with-like C2 symmetry not present |

P(E4|∼T) | 0.3 | strongly inconsistent | Triple-helix C2 symmetry not present |

P(E5|T) | 0.3 | strongly inconsistent | Like-with-like Chargaff’s rules violated |

P(E5|∼T) | 0.3 | strongly inconsistent | Triple-helix Chargaff’s rules violated |

P(E6|T) | 0.3 | strongly inconsistent | Like-with-like hydrogen-bonding incorrect |

P(E6|∼T) | 0.3 | strongly inconsistent | Triple-helix hydrogen-bonds not possible |

P(E7|T) | 0.6 | weakly consistent | Like-with-like replication mechanism possible |

P(E7|∼T) | 0.4 | weakly inconsistent | Triple-helix had no replication mechanism |

P(T|E1–E7) | 0.32 | confirm | % change = +33.3, LR = 1.5 |

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. No content on this site may be used to train artificial intelligence systems without permission in writing from the MIT Press.