Watson and Crick’s final double helix model (like-with-like as the alternative)
Probability . | Estimate . | Interpretation . | Evidence . |
---|---|---|---|
P(T) | 0.32 | prior of T | posterior of like-with-like model |
P(∼T) | 0.68 | prior of not T | 1 − prior |
P(E1|T) | 0.7 | strongly consistent | X-ray picture of B-form supports helix via theory |
P(E1|∼T) | 0.7 | strongly consistent | Like-with-like model is also a helix |
P(E2|T) | 0.7 | strongly consistent | 34 Å crystallographic repeat (B form X-ray picture) |
P(E2|∼T) | 0.3 | strongly inconsistent | Like-with-like model did not give a 34 Å repeat |
P(E3|T) | 0.7 | strongly consistent | bond lengths fit |
P(E3|∼T) | 0.3 | strongly inconsistent | Like-with-like bond lengths did not fit |
P(E4|T) | 0.7 | strongly consistent | C2 symmetry of structure |
P(E4|∼T) | 0.3 | strongly inconsistent | Like-with-like model lacked C2 symmetry |
P(E5|T) | 0.7 | strongly consistent | obeys Chargaff’s rules |
P(E5|∼T) | 0.3 | strongly inconsistent | Like-with-like inconsistent with Chargaff rules |
P(E6|T) | 0.7 | strongly consistent | hydrogen bonding of bases correct |
P(E6|∼T) | 0.3 | strongly inconsistent | Like-with-like model has hydrogen bonding wrong |
P(E7|T) | 0.6 | weakly consistent | mechanism for replication suggested |
P(E7|∼T) | 0.6 | weakly consistent | Like-with-like also gave mechanism for replication |
P(T|E1–E7) | 0.97 | Confirm | % change = +203.1, LR = 69.2 |
Probability . | Estimate . | Interpretation . | Evidence . |
---|---|---|---|
P(T) | 0.32 | prior of T | posterior of like-with-like model |
P(∼T) | 0.68 | prior of not T | 1 − prior |
P(E1|T) | 0.7 | strongly consistent | X-ray picture of B-form supports helix via theory |
P(E1|∼T) | 0.7 | strongly consistent | Like-with-like model is also a helix |
P(E2|T) | 0.7 | strongly consistent | 34 Å crystallographic repeat (B form X-ray picture) |
P(E2|∼T) | 0.3 | strongly inconsistent | Like-with-like model did not give a 34 Å repeat |
P(E3|T) | 0.7 | strongly consistent | bond lengths fit |
P(E3|∼T) | 0.3 | strongly inconsistent | Like-with-like bond lengths did not fit |
P(E4|T) | 0.7 | strongly consistent | C2 symmetry of structure |
P(E4|∼T) | 0.3 | strongly inconsistent | Like-with-like model lacked C2 symmetry |
P(E5|T) | 0.7 | strongly consistent | obeys Chargaff’s rules |
P(E5|∼T) | 0.3 | strongly inconsistent | Like-with-like inconsistent with Chargaff rules |
P(E6|T) | 0.7 | strongly consistent | hydrogen bonding of bases correct |
P(E6|∼T) | 0.3 | strongly inconsistent | Like-with-like model has hydrogen bonding wrong |
P(E7|T) | 0.6 | weakly consistent | mechanism for replication suggested |
P(E7|∼T) | 0.6 | weakly consistent | Like-with-like also gave mechanism for replication |
P(T|E1–E7) | 0.97 | Confirm | % change = +203.1, LR = 69.2 |